Xarelto (Rivaroxaban) dosage: For treating DVT or PE, the typical dose is 15 mg twice daily with food for the first 21 days. For nonvalvular atrial fibrillation, the typical starting dose is either 15 or 20 mg once in the evening, with a meal. To prevent DVT or PE, people usually take 10 mg of Xarelto once a day, with or without food. After hip or knee replacement surgery, the usual recommendation is to start treatment at least 6 to 10 hours after surgery. People who’ve had a hip replacement generally are prescribed 10 mg of the drug.