How to take Levofloxacin. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take Levofloxacin with water, at the same time each day. Drink extra fluids to keep your kidneys working properly while taking this medicine. You may take Levofloxacin tablets with or without food. Take Levofloxacin oral solution (liquid) on an empty stomach, at least 1 hour before or 2 hours after a meal.