Rifaximin, sold under the trade name Xifaxan. Rifaximin is a semi-synthetic antibiotic used for treating traveler’s diarrhea and hepatic encephalopathy. Rifaximin is active against Escherichia coli bacterial strains that cause traveler’s diarrhea, preventing growth of the bacteria by preventing them from manufacturing proteins needed for their survival.

Rifaximin interactions. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.