Lubiprostone ( marketed under the trade name Amitiza) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. Lubiprostone is for use only in adults. Lubiprostone may also be used for purposes not listed in this medication guide.

Lubiprostone precautions. Before taking lubiprostone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain stomach/intestinal problems (blockage, severe diarrhea), liver disease.